Gail Cassell

Gail H Cassell, Ph.D.

Senior Lecturer on Global Health and Social Medicine, Part-time

gail.h.cassell@gmai.com

Tabs

Research

Dr. Cassell is a leader on efforts to address multidrug-resistant tuberculosis (MDRTB). She and Barry Bloom, former dean of Harvard School of Public Health, co-lead an Institute of Medicine project on drug supply chain issues related to MDRTB. She actively advises numerous government agencies, NGOs, and foundations on the scale-up of MDRTB diagnosis and treatment in endemic areas around the world, including in Russia.

Dr. Cassell is advising the GHSM Sentinel Project on pediatric drug-resistant tuberculosis, a global partnership that aims to develop and deploy evidence-based strategies to prevent child deaths from drug-resistant tuberculosis.

Biography

Dr. Cassell is vice president for TB Drug Development at the Infectious Disease Research Institute in Seattle, Washington, professor emeritus and former chair, Department of Microbiology, University of Alabama at Birmingham, and former vice president for scientific affairs and distinguished Lilly research scholar for infectious diseases at Eli Lilly and Company in Indianapolis, Indiana. She founded the Forum on Drug Discovery, Development and Translation, which she continues to co-chair, at the Institute of Medicine. She has a distinguished record of national service with the National Academy of Sciences, National Institutes of Health, Centers for Disease Control, and several other national and international institutions.

Publications

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.

Gail H Cassell, Ph.D.

Nature genetics, January 16, 2017

Manson AL, Cohen KA, Abeel T, Desjardins CA, Armstrong DT, Barry CE, Brand J, Chapman SB, Cho SN, Gabrielian A, Gomez J, Jodals AM, Joloba M, Jureen P, Lee JS, Malinga L, Maiga M, Nordenberg D, Noroc E, Romancenco E, Salazar A, Ssengooba W, Velayati AA...

Link to abstract on PubMed

Investigation of isoniazid and ethionamide cross-resistance by whole genome sequencing and association with poor treatment outcomes of multidrug-resistant tuberculosis patients in South Africa.

Gail H Cassell, Ph.D.

International journal of mycobacteriology, November 25, 2016

Malinga L, Brand J, Jansen van Rensburg C, Cassell G, van der Walt M

Link to abstract on PubMed

Differential recognition of the multiple banded antigen isoforms across Ureaplasma parvum and Ureaplasma urealyticum species by monoclonal antibodies.

Gail H Cassell, Ph.D.

Journal of microbiological methods, May 18, 2016

Aboklaish AF, Ahmed S, McAllister D, Cassell G, Zheng XT, Spiller OB

Link to abstract on PubMed

Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage.

Gail H Cassell, Ph.D.

Genome announcements, March 3, 2016

Malinga LA, Abeel T, Desjardins CA, Dlamini TC, Cassell G, Chapman SB, Birren BW, Earl AM, van der Walt M

Link to abstract on PubMed

Populations of latent Mycobacterium tuberculosis lack a cell wall: Isolation, visualization, and whole-genome characterization.

Gail H Cassell, Ph.D.

International journal of mycobacteriology, December 28, 2015

Velayati AA, Abeel T, Shea T, Konstantinovich Zhavnerko G, Birren B, Cassell GH, Earl AM, Hoffner S, Farnia P

Link to abstract on PubMed

Community-based care vs. centralised hospitalisation for MDR-TB patients, KwaZulu-Natal, South Africa.

Gail H Cassell, Ph.D.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, February 1, 2015

Loveday M, Wallengren K, Brust J, Roberts J, Voce A, Margot B, Ngozo J, Master I, Cassell G, Padayatchi N

Link to abstract on PubMed

Shifting gears to control drug-resistant tuberculosis.

Gail H Cassell, Ph.D., Salmaan A. Keshavjee, MD, PhD

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, June 18, 2014

Berkelman RL, Cassell GH, Whitney EA, Keshavjee S

Link to abstract on PubMed

Inflammation and tuberculosis: host-directed therapies.

Gail H Cassell, Ph.D.

Journal of internal medicine, May 19, 2014

Zumla A, Rao M, Parida SK, Keshavjee S, Cassell G, Wallis R, Axelsson-Robertsson R, Doherty M, Andersson J, Maeurer M

Link to abstract on PubMed

Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains.

Gail H Cassell, Ph.D.

BMC microbiology, May 30, 2012

Paralanov V, Lu J, Duffy LB, Crabb DM, Shrivastava S, Methé BA, Inman J, Yooseph S, Xiao L, Cassell GH, Waites KB, Glass JI

Link to abstract on PubMed

Outcomes of multi-drug resistant tuberculosis (MDR-TB) among a cohort of South African patients with high HIV prevalence.

Gail H Cassell, Ph.D.

PloS one, July 22, 2011

Farley JE, Ram M, Pan W, Waldman S, Cassell GH, Chaisson RE, Weyer K, Lancaster J, Van der Walt M

Link to abstract on PubMed

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Affiliations

Division of Global Health Equity, Brigham and Women's Hospital

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Tabs

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.

Investigation of isoniazid and ethionamide cross-resistance by whole genome sequencing and association with poor treatment outcomes of multidrug-resistant tuberculosis patients in South Africa.

Differential recognition of the multiple banded antigen isoforms across Ureaplasma parvum and Ureaplasma urealyticum species by monoclonal antibodies.

Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage.

Populations of latent Mycobacterium tuberculosis lack a cell wall: Isolation, visualization, and whole-genome characterization.

Community-based care vs. centralised hospitalisation for MDR-TB patients, KwaZulu-Natal, South Africa.

Shifting gears to control drug-resistant tuberculosis.

Inflammation and tuberculosis: host-directed therapies.

Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains.

Outcomes of multi-drug resistant tuberculosis (MDR-TB) among a cohort of South African patients with high HIV prevalence.