Health policy is an underutilized tool to address the economic, social, and cultural disparities that fuel social vulnerabilities and discord. There is growing appreciation that improvements in population health can reduce poverty and contribute to long-term security and economic growth. Interventions for human immunodeficiency virus (HIV), tuberculosis, and vaccine-preventable illnesses, for example, have all improved economies and demonstrated that, just as disease transcends borders and can adversely affect regional economies, sound investments in health promotion can have a positive effect. The challenges are significant, the world is striving to achieve the Sustainable Development Goals. To address these challenges and the complex interplay of health, poverty, education, governance, security, and environment, the field of medicine must become a partner to global public policy, global health care policy, global security, and foreign policy. The Program in Global Public Policy and Social Change (PGPPSC) aims to embrace this complex intersection and help develop the needed partnerships among the fields of global health, public policy, security, and diplomacy. PGPPSC works collaboratively across Harvard departments and institutions and engages undergraduates, graduate students, faculty, and key policymakers from the public, private, and non-governmental sector to provide innovative solutions to global public policy problems.