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Alexandra Golby, MD

Professor of Neurosurgery, Harvard Medical School
Professor of Radiology, Harvard Medical School
Department of Global Health and Social Medicine Affiliate
Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
Senior Surgeon, Brigham and Women's Hospital
Director of Image-guided Neurosurgery, Brigham and Women's Hospital
Co-Director AMIGO, Brigham and Women's Hospital

Dr. Golby is a Neurosurgeon and Haley Distinguished Chair in the Neurosciences at Brigham and Women’s Hospital in Boston. She is Professor of Neurosurgery and Professor of Radiology at Harvard Medical School.  She is also Principal Investigator of the Golby Lab, a surgical brain mapping laboratory. Dr. Golby’s clinical focus is on brain surgery for patients with brain tumors and epilepsy, especially those lesions which are intimately associated with critical brain structures. Her translational research is focused on advanced imaging and image guidance to improve care for patients undergoing intracranial neurosurgery. She has developed numerous technologies to help guide presurgical planning and intraoperative decision-making. She works closely with scientists across disciplines including computer science, applied mathematics, MR and ultrasound physics, radiology, neuroscience, and biomedical engineering. She is very involved with mentoring young clinicians and scientists both locally and globally. Dr. Golby was recently a Fulbright Global Scholar pursuing work to foster interdisciplinary collaborations between technical experts and clinicians in host countries Rwanda and Morocco to develop innovative medical technology suited to local conditions.

Dr. Golby received her BA from Yale University and MD from Stanford University School of Medicine. She completed residency training in Neurosurgery at Brigham and Women’s Hospital.

The Golby Lab is a multidisciplinary team of investigators using advanced imaging, image analysis, and computational strategies to develop novel approaches to guide neurosurgery. Areas of interest include using functional MRI to map cortical organization and diffusion MRI to map white matter connections, intra-operative imaging, navigation and guidance, and image guided therapies for brain tumors. She is the co-director of AMIGO, the advanced multi-modality Image guided OR, an NIH-funded translational research operating suite where surgeons and interventionalists work with radiologists and technical experts to develop novel therapies to provide precise, minimally invasive, and effective treatments to patients. She leads the development of NousNav a low-cost open-source neuronavigation system for use in resource-limited settings.

Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes.
Authors: Authors: Sefcikova V, Sporrer JK, Juvekar P, Golby A, Samandouras G.
Brain Struct Funct
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Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.
Authors: Authors: Bhere D, Choi SH, van de Donk P, Hope D, Gortzak K, Kunnummal A, Khalsa J, Revai Lechtich E, Reinshagen C, Leon V, Nissar N, Bi WL, Feng C, Li H, Zhang YS, Liang SH, Vasdev N, Essayed W, Quevedo PV, Golby A, Banouni N, Palagina A, Abdi R, Fury B, Smirnakis S, Lowe A, Reeve B, Hiller A, Chiocca EA, Prestwich G, Wakimoto H, Bauer G, Shah K.
Nat Commun
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Pose Estimation and Non-Rigid Registration for Augmented Reality During Neurosurgery.
Authors: Authors: Haouchine N, Juvekar P, Nercessian M, Wells W, Golby A, Frisken S.
IEEE Trans Biomed Eng
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Automatic framework for patient-specific modelling of tumour resection-induced brain shift.
Authors: Authors: Yu Y, Safdar S, Bourantas G, Zwick B, Joldes G, Kapur T, Frisken S, Kikinis R, Nabavi A, Golby A, Wittek A, Miller K.
Comput Biol Med
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Multimodal Intraoperative Image-Driven Surgery for Skull Base Chordomas and Chondrosarcomas.
Authors: Authors: Essayed WI, Juvekar P, Bernstock JD, Rassi MS, Almefty K, Zamani AA, Golby AJ, Al-Mefty O.
Cancers (Basel)
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White matter association tracts underlying language and theory of mind: An investigation of 809 brains from the Human Connectome Project.
Authors: Authors: Zekelman LR, Zhang F, Makris N, He J, Chen Y, Xue T, Liera D, Drane DL, Rathi Y, Golby AJ, O'Donnell LJ.
Neuroimage
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Movie-watching fMRI for presurgical language mapping in patients with brain tumour.
Authors: Authors: Yao S, Rigolo L, Yang F, Vangel MG, Wang H, Golby AJ, Liebenthal E, Tie Y.
J Neurol Neurosurg Psychiatry
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The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors.
Authors: Authors: Peruzzi P, Valdes PQ, Aghi MK, Berger M, Chiocca EA, Golby AJ.
Hematol Oncol Clin North Am
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Computer simulation of tumour resection-induced brain deformation by a meshless approach.
Authors: Authors: Yu Y, Bourantas G, Zwick B, Joldes G, Kapur T, Frisken S, Kikinis R, Nabavi A, Golby A, Wittek A, Miller K.
Int J Numer Method Biomed Eng
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Tumor BOLD connectivity profile correlates with glioma patients' survival.
Authors: Authors: Sprugnoli G, Rigolo L, Faria M, Juvekar P, Tie Y, Rossi S, Sverzellati N, Golby AJ, Santarnecchi E.
Neurooncol Adv
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