Molly F

Molly Forrest Franke, SD

Associate Professor of Global Health and Social Medicine
Co-Director, Global and Community Health Advanced Integrated Science Course (AISC)
Epidemiologist, Global Health Research Core

Molly Franke is associate professor in the Department of Global Health and Social Medicine at Harvard Medical School. She co-directs the HMS Global and Community Health Advanced Integrated Science Course (AISC) and is a member of the Department’s Global Health Research Core.

Franke completed undergraduate studies in Sociology and Spanish at Colby College and doctoral training in Epidemiology at the Harvard T.H. Chan School of Public Health. Prior to joining the Department in 2010, she worked for Massachusetts Department of Public Health Epidemiology & Immunization Surveillance Program and Partners In Health sites in Peru and Rwanda. She is a long-time volunteer with the Elm Project, which supports underserved youth affected by chronic illness.

Throughout her career, Dr. Franke has contributed to the learning of dozens of students and trainees within the Harvard community, at other institutions of higher learning and the field sites where she conducts research. She is an active participant in the HMS Masters of Medical Sciences in Global Health Delivery (MMSc-GHD) program, serving as a thesis advisor and member of the Curriculum and Admissions Committees. She has been recognized for excellence in mentoring: in 2017 she received the Jo Rae Wright Award for promising contributions in pulmonary research along with outstanding mentoring and professional leadership qualities, and in 2020 she was awarded the Young Mentor Award by Harvard Medical School.

Dr. Franke is a global health researcher whose work brings the rigor of epidemiology to intractable infections (tuberculosis [TB], cholera, HIV, SARS-CoV-2) and chronic diseases (diabetes, hypertension depression) that disproportionately affect the poor or socially-marginalized. Her work has spanned a range of settings including Peru, Haiti, Rwanda, Mexico, Papua New Guinea, and the United States.

Franke’s current work has two broad objectives. The first is improve the health of children and adolescents affected by TB and HIV. She is the PI of a Peru-based pediatric tuberculosis diagnostic study that aims to identify the best non-sputum-based specimens from which to detect TB in children. She also leads intervention work in Peru that aims to improve the health and well-being of adolescents and young adults living with HIV through the provision of health navigation and social support and through youth-friendly modalities, such as music videos (https://vimeo.com/280933246).

The second objective of her work is to ensure that care and treatment of health conditions that disproportionately affect the poor and socially marginalized is guided by the highest possible quality of evidence. To this end, she seeks to identify and apply the best epidemiologic methods for addressing critical knowledge gaps related to interventions and treatment.  Her past work has included the development and validation of questionnaires; design of studies to assess the effectiveness of cholera interventions, including vaccination; and assessment of community-based programs for care and treatment of HIV, tuberculosis, mental health, diabetes and hypertension. Franke currently holds funding from the National Institutes of Health to improve the evidence base guiding treatment of drug-resistant TB through the application and adaptation of statistical methods commonly used in other fields.

Diagnostic accuracy of molecular detection of Mycobacterium tuberculosis in pediatric stool samples: A systematic review and meta-analysis.
Authors: Authors: Mesman AW, Rodriguez C, Ager E, Coit J, Trevisi L, Franke MF.
Tuberculosis (Edinb)
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Performance of a household tuberculosis exposure survey among children in a Latin American setting.
Authors: Authors: Coit J, Mendoza M, Pinedo C, Marin H, Chiang SS, Lecca L, Franke M.
Int J Tuberc Lung Dis
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Understanding health-related behavior among adolescents living with HIV in Lima, Peru.
Authors: Authors: Rodriguez CA, Valle E, Galea J, Wong M, Kolevic L, Muñoz M, Lecca L, Franke MF.
BMC Pediatr
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Correction to: Detection of Mycobacterium tuberculosis in pediatric stool samples using TruTip technology.
Authors: Authors: Mesman AW, Soto M, Coit J, Calderon R, Aliaga J, Pollock NR, Mendoza M, Mestanza FM, Mendoza CJ, Murray MB, Lecca L, Holmberg R, Franke MF.
BMC Infect Dis
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Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis.
Authors: Authors: Aibana O, Huang CC, Aboud S, Arnedo-Pena A, Becerra MC, Bellido-Blasco JB, Bhosale R, Calderon R, Chiang S, Contreras C, Davaasambuu G, Fawzi WW, Franke MF, Galea JT, Garcia-Ferrer D, Gil-Fortuño M, Gomila-Sard B, Gupta A, Gupte N, Hussain R, Iborra-Millet J, Iqbal NT, Juan-Cerdán JV, Kinikar A, Lecca L, Mave V, Meseguer-Ferrer N, Montepiedra G, Mugusi FM, Owolabi OA, Parsonnet J, Roach-Poblete F, Romeu-García MA, Spector SA, Sudfeld CR, Tenforde MW, Togun TO, Yataco R, Zhang Z, Murray MB.
PLoS Med
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Value of observational data for multidrug-resistant tuberculosis.
Authors: Authors: Rodriguez CA, Mitnick CD, Franke MF.
Lancet Infect Dis
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The endTB observational study protocol: treatment of MDR-TB with bedaquiline or delamanid containing regimens.
Authors: Authors: Khan U, Huerga H, Khan AJ, Mitnick CD, Hewison C, Varaine F, Bastard M, Rich M, Franke MF, Atwood S, Khan PY, Seung KJ.
BMC Infect Dis
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Causal inference in tuberculosis treatment studies: bias considerations and data needs.
Authors: Authors: Franke MF, Rodriguez CA, Mitnick CD.
Int J Tuberc Lung Dis
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Detection of Mycobacterium tuberculosis in pediatric stool samples using TruTip technology.
Authors: Authors: Mesman AW, Soto M, Coit J, Calderon R, Aliaga J, Pollock NR, Mendoza M, Mestanza FM, Mendoza CJ, Murray MB, Lecca L, Holmberg R, Franke MF.
BMC Infect Dis
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Mycobacterium tuberculosis detection from oral swabs with Xpert MTB/RIF ULTRA: a pilot study.
Authors: Authors: Mesman AW, Calderon R, Soto M, Coit J, Aliaga J, Mendoza M, Franke MF.
BMC Res Notes
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