Image of Alexandra Golby

Alexandra Golby, MD

Professor of Neurosurgery, Harvard Medical School
Professor of Radiology, Harvard Medical School
Department of Global Health and Social Medicine Affiliate
Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
Senior Surgeon, Brigham and Women's Hospital
Director of Image-guided Neurosurgery, Brigham and Women's Hospital
Co-Director AMIGO, Brigham and Women's Hospital

Dr. Golby is a Neurosurgeon and Haley Distinguished Chair in the Neurosciences at Brigham and Women’s Hospital in Boston. She is Professor of Neurosurgery and Professor of Radiology at Harvard Medical School.  She is also Principal Investigator of the Golby Lab, a surgical brain mapping laboratory. Dr. Golby’s clinical focus is on brain surgery for patients with brain tumors and epilepsy, especially those lesions which are intimately associated with critical brain structures. Her translational research is focused on advanced imaging and image guidance to improve care for patients undergoing intracranial neurosurgery. She has developed numerous technologies to help guide presurgical planning and intraoperative decision-making. She works closely with scientists across disciplines including computer science, applied mathematics, MR and ultrasound physics, radiology, neuroscience, and biomedical engineering. She is very involved with mentoring young clinicians and scientists both locally and globally. Dr. Golby was recently a Fulbright Global Scholar pursuing work to foster interdisciplinary collaborations between technical experts and clinicians in host countries Rwanda and Morocco to develop innovative medical technology suited to local conditions.

Dr. Golby received her BA from Yale University and MD from Stanford University School of Medicine. She completed residency training in Neurosurgery at Brigham and Women’s Hospital.

The Golby Lab is a multidisciplinary team of investigators using advanced imaging, image analysis, and computational strategies to develop novel approaches to guide neurosurgery. Areas of interest include using functional MRI to map cortical organization and diffusion MRI to map white matter connections, intra-operative imaging, navigation and guidance, and image guided therapies for brain tumors. She is the co-director of AMIGO, the advanced multi-modality Image guided OR, an NIH-funded translational research operating suite where surgeons and interventionalists work with radiologists and technical experts to develop novel therapies to provide precise, minimally invasive, and effective treatments to patients. She leads the development of NousNav a low-cost open-source neuronavigation system for use in resource-limited settings.

Superficial white matter analysis: An efficient point-cloud-based deep learning framework with supervised contrastive learning for consistent tractography parcellation across populations and dMRI acquisitions.
Authors: Authors: Xue T, Zhang F, Zhang C, Chen Y, Song Y, Golby AJ, Makris N, Rathi Y, Cai W, O'Donnell LJ.
Med Image Anal
View full abstract on Pubmed
Global cancer surgery in low-resource settings: A strengths, weaknesses, opportunities, and threats analysis.
Authors: Authors: Sadler SJ, Torio EF, Golby AJ.
Cancer
View full abstract on Pubmed
Mapping Resection Progress by Tool-Tip Tracking during Brain Tumor Surgery for Real-Time Estimation of Residual Tumor.
Authors: Authors: Juvekar P, Torio E, Bi WL, Bastos DCA, Golby AJ, Frisken SF.
Cancers (Basel)
View full abstract on Pubmed
A Tool-free Neuronavigation Method based on Single-view Hand Tracking.
Authors: Authors: Kögl FV, Léger É, Haouchine N, Torio E, Juvekar P, Navab N, Kapur T, Pieper S, Golby A, Frisken S.
Comput Methods Biomech Biomed Eng Imaging Vis
View full abstract on Pubmed
Directionally encoded color track density imaging in brain tumor patients: A potential application to neuro-oncology surgical planning.
Authors: Authors: Sullivan JJ, Zekelman LR, Zhang F, Juvekar P, Torio EF, Bunevicius A, Essayed WI, Bastos D, He J, Rigolo L, Golby AJ, O'Donnell LJ.
Neuroimage Clin
View full abstract on Pubmed
Comparison of physics-based deformable registration methods for image-guided neurosurgery.
Authors: Authors: Chrisochoides N, Liu Y, Drakopoulos F, Kot A, Foteinos P, Tsolakis C, Billias E, Clatz O, Ayache N, Fedorov A, Golby A, Black P, Kikinis R.
Front Digit Health
View full abstract on Pubmed
Transcranial MR-Guided Focused Ultrasound and Hyperostosis Calvariae Diffusa: Case Report and Systematic Review of the Literature.
Authors: Authors: Bernstock JD, Torio EF, Raghu ALB, Chua M, Chen JA, Segar D, Gupta S, White PJ, McDannold N, Golby AJ, Cosgrove GR.
Stereotact Funct Neurosurg
View full abstract on Pubmed
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function.
Authors: Authors: Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC.
Science
View full abstract on Pubmed
NousNav: A low-cost neuronavigation system for deployment in lower-resource settings.
Authors: Authors: Léger É, Horvath S, Fillion-Robin JC, Allemang D, Gerber S, Juvekar P, Torio E, Kapur T, Pieper S, Pujol S, Bardsley R, Frisken S, Golby A.
Int J Comput Assist Radiol Surg
View full abstract on Pubmed
Using temporal and structural data to reconstruct 3D cerebral vasculature from a pair of 2D digital subtraction angiography sequences.
Authors: Authors: Frisken S, Haouchine N, Du R, Golby AJ.
Comput Med Imaging Graph
View full abstract on Pubmed