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Alexandra Golby, MD

Professor of Neurosurgery, Harvard Medical School
Professor of Radiology, Harvard Medical School
Department of Global Health and Social Medicine Affiliate
Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
Senior Surgeon, Brigham and Women's Hospital
Director of Image-guided Neurosurgery, Brigham and Women's Hospital
Co-Director AMIGO, Brigham and Women's Hospital

Dr. Golby is a Neurosurgeon and Haley Distinguished Chair in the Neurosciences at Brigham and Women’s Hospital in Boston. She is Professor of Neurosurgery and Professor of Radiology at Harvard Medical School.  She is also Principal Investigator of the Golby Lab, a surgical brain mapping laboratory. Dr. Golby’s clinical focus is on brain surgery for patients with brain tumors and epilepsy, especially those lesions which are intimately associated with critical brain structures. Her translational research is focused on advanced imaging and image guidance to improve care for patients undergoing intracranial neurosurgery. She has developed numerous technologies to help guide presurgical planning and intraoperative decision-making. She works closely with scientists across disciplines including computer science, applied mathematics, MR and ultrasound physics, radiology, neuroscience, and biomedical engineering. She is very involved with mentoring young clinicians and scientists both locally and globally. Dr. Golby was recently a Fulbright Global Scholar pursuing work to foster interdisciplinary collaborations between technical experts and clinicians in host countries Rwanda and Morocco to develop innovative medical technology suited to local conditions.

Dr. Golby received her BA from Yale University and MD from Stanford University School of Medicine. She completed residency training in Neurosurgery at Brigham and Women’s Hospital.

The Golby Lab is a multidisciplinary team of investigators using advanced imaging, image analysis, and computational strategies to develop novel approaches to guide neurosurgery. Areas of interest include using functional MRI to map cortical organization and diffusion MRI to map white matter connections, intra-operative imaging, navigation and guidance, and image guided therapies for brain tumors. She is the co-director of AMIGO, the advanced multi-modality Image guided OR, an NIH-funded translational research operating suite where surgeons and interventionalists work with radiologists and technical experts to develop novel therapies to provide precise, minimally invasive, and effective treatments to patients. She leads the development of NousNav a low-cost open-source neuronavigation system for use in resource-limited settings.

Multimodal imaging for improved diagnosis and treatment of cancers.
Authors: Authors: Tempany CM, Jayender J, Kapur T, Bueno R, Golby A, Agar N, Jolesz FA.
Cancer
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Comparative effectiveness of frame-based, frameless, and intraoperative magnetic resonance imaging-guided brain biopsy techniques.
Authors: Authors: Lu Y, Yeung C, Radmanesh A, Wiemann R, Black PM, Golby AJ.
World Neurosurg
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Comparison of seeding methods for visualization of the corticospinal tracts using single tensor tractography.
Authors: Authors: Radmanesh A, Zamani AA, Whalen S, Tie Y, Suarez RO, Golby AJ.
Clin Neurol Neurosurg
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Smart stylet: the development and use of a bedside external ventricular drain image-guidance system.
Authors: Authors: Patil V, Gupta R, San José Estépar R, Lacson R, Cheung A, Wong JM, Popp AJ, Golby A, Ogilvy C, Vosburgh KG.
Stereotact Funct Neurosurg
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A New Paradigm for Individual Subject Language Mapping: Movie-Watching fMRI.
Authors: Authors: Tie Y, Rigolo L, Ozdemir Ovalioglu A, Olubiyi O, Doolin KL, Mukundan S, Golby AJ.
J Neuroimaging
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The DTI Challenge: Toward Standardized Evaluation of Diffusion Tensor Imaging Tractography for Neurosurgery.
Authors: Authors: Pujol S, Wells W, Pierpaoli C, Brun C, Gee J, Cheng G, Vemuri B, Commowick O, Prima S, Stamm A, Goubran M, Khan A, Peters T, Neher P, Maier-Hein KH, Shi Y, Tristan-Vega A, Veni G, Whitaker R, Styner M, Westin CF, Gouttard S, Norton I, Chauvin L, Mamata H, Gerig G, Nabavi A, Golby A, Kikinis R.
J Neuroimaging
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Multimodal navigated skull base tumor resection using image-based vascular and cranial nerve segmentation: A prospective pilot study.
Authors: Authors: Dolati P, Gokoglu A, Eichberg D, Zamani A, Golby A, Al-Mefty O.
Surg Neurol Int
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Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography.
Authors: Authors: Chen Z, Tie Y, Olubiyi O, Rigolo L, Mehrtash A, Norton I, Pasternak O, Rathi Y, Golby AJ, O'Donnell LJ.
Neuroimage Clin
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"Countersinking" of reservoir in an irradiated patients can decrease tension on scalp closure.
Authors: Authors: Singh M, Rios Diaz AJ, Golby AJ, Caterson EJ.
Surg Neurol Int
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Decoupling function and anatomy in atlases of functional connectivity patterns: language mapping in tumor patients.
Authors: Authors: Langs G, Sweet A, Lashkari D, Tie Y, Rigolo L, Golby AJ, Golland P.
Neuroimage
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