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Alexandra Golby, MD

Professor of Neurosurgery, Harvard Medical School
Professor of Radiology, Harvard Medical School
Department of Global Health and Social Medicine Affiliate
Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
Senior Surgeon, Brigham and Women's Hospital
Director of Image-guided Neurosurgery, Brigham and Women's Hospital
Co-Director AMIGO, Brigham and Women's Hospital

Dr. Golby is a Neurosurgeon and Haley Distinguished Chair in the Neurosciences at Brigham and Women’s Hospital in Boston. She is Professor of Neurosurgery and Professor of Radiology at Harvard Medical School.  She is also Principal Investigator of the Golby Lab, a surgical brain mapping laboratory. Dr. Golby’s clinical focus is on brain surgery for patients with brain tumors and epilepsy, especially those lesions which are intimately associated with critical brain structures. Her translational research is focused on advanced imaging and image guidance to improve care for patients undergoing intracranial neurosurgery. She has developed numerous technologies to help guide presurgical planning and intraoperative decision-making. She works closely with scientists across disciplines including computer science, applied mathematics, MR and ultrasound physics, radiology, neuroscience, and biomedical engineering. She is very involved with mentoring young clinicians and scientists both locally and globally. Dr. Golby was recently a Fulbright Global Scholar pursuing work to foster interdisciplinary collaborations between technical experts and clinicians in host countries Rwanda and Morocco to develop innovative medical technology suited to local conditions.

Dr. Golby received her BA from Yale University and MD from Stanford University School of Medicine. She completed residency training in Neurosurgery at Brigham and Women’s Hospital.

The Golby Lab is a multidisciplinary team of investigators using advanced imaging, image analysis, and computational strategies to develop novel approaches to guide neurosurgery. Areas of interest include using functional MRI to map cortical organization and diffusion MRI to map white matter connections, intra-operative imaging, navigation and guidance, and image guided therapies for brain tumors. She is the co-director of AMIGO, the advanced multi-modality Image guided OR, an NIH-funded translational research operating suite where surgeons and interventionalists work with radiologists and technical experts to develop novel therapies to provide precise, minimally invasive, and effective treatments to patients. She leads the development of NousNav a low-cost open-source neuronavigation system for use in resource-limited settings.

Functional Geometry Alignment and Localization of Brain Areas.
Authors: Authors: Langs G, Golland P, Tie Y, Rigolo L, Golby AJ.
Adv Neural Inf Process Syst
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OpenIGTLink: an open network protocol for image-guided therapy environment.
Authors: Authors: Tokuda J, Fischer GS, Papademetris X, Yaniv Z, Ibanez L, Cheng P, Liu H, Blevins J, Arata J, Golby AJ, Kapur T, Pieper S, Burdette EC, Fichtinger G, Tempany CM, Hata N.
Int J Med Robot
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Threshold-independent functional MRI determination of language dominance: a validation study against clinical gold standards.
Authors: Authors: Suarez RO, Whalen S, Nelson AP, Tie Y, Meadows ME, Radmanesh A, Golby AJ.
Epilepsy Behav
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Comparison of blocked and event-related fMRI designs for pre-surgical language mapping.
Authors: Authors: Tie Y, Suarez RO, Whalen S, Radmanesh A, Norton IH, Golby AJ.
Neuroimage
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Orbitocranial wooden foreign body: a pre-, intra-, and postoperative chronicle: case report.
Authors: Authors: Dunn IF, Kim DH, Rubin PA, Blinder R, Gates J, Golby AJ.
Neurosurgery
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Resolving crossings in the corticospinal tract by two-tensor streamline tractography: Method and clinical assessment using fMRI.
Authors: Authors: Qazi AA, Radmanesh A, O'Donnell L, Kindlmann G, Peled S, Whalen S, Westin CF, Golby AJ.
Neuroimage
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High b-value apparent diffusion-weighted images from CURVE-ball DTI.
Authors: Authors: Peled S, Whalen S, Jolesz FA, Golby AJ.
J Magn Reson Imaging
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Tract-based morphometry for white matter group analysis.
Authors: Authors: O'Donnell LJ, Westin CF, Golby AJ.
Neuroimage
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Origins of intraoperative MRI.
Authors: Authors: Mislow JM, Golby AJ, Black PM.
Neurosurg Clin N Am
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An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results.
Authors: Authors: White PJ, Whalen S, Tang SC, Clement GT, Jolesz F, Golby AJ.
J Ultrasound Med
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