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Alexandra Golby, MD

Professor of Neurosurgery, Harvard Medical School
Professor of Radiology, Harvard Medical School
Department of Global Health and Social Medicine Affiliate
Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
Senior Surgeon, Brigham and Women's Hospital
Director of Image-guided Neurosurgery, Brigham and Women's Hospital
Co-Director AMIGO, Brigham and Women's Hospital

Dr. Golby is a Neurosurgeon and Haley Distinguished Chair in the Neurosciences at Brigham and Women’s Hospital in Boston. She is Professor of Neurosurgery and Professor of Radiology at Harvard Medical School.  She is also Principal Investigator of the Golby Lab, a surgical brain mapping laboratory. Dr. Golby’s clinical focus is on brain surgery for patients with brain tumors and epilepsy, especially those lesions which are intimately associated with critical brain structures. Her translational research is focused on advanced imaging and image guidance to improve care for patients undergoing intracranial neurosurgery. She has developed numerous technologies to help guide presurgical planning and intraoperative decision-making. She works closely with scientists across disciplines including computer science, applied mathematics, MR and ultrasound physics, radiology, neuroscience, and biomedical engineering. She is very involved with mentoring young clinicians and scientists both locally and globally. Dr. Golby was recently a Fulbright Global Scholar pursuing work to foster interdisciplinary collaborations between technical experts and clinicians in host countries Rwanda and Morocco to develop innovative medical technology suited to local conditions.

Dr. Golby received her BA from Yale University and MD from Stanford University School of Medicine. She completed residency training in Neurosurgery at Brigham and Women’s Hospital.

The Golby Lab is a multidisciplinary team of investigators using advanced imaging, image analysis, and computational strategies to develop novel approaches to guide neurosurgery. Areas of interest include using functional MRI to map cortical organization and diffusion MRI to map white matter connections, intra-operative imaging, navigation and guidance, and image guided therapies for brain tumors. She is the co-director of AMIGO, the advanced multi-modality Image guided OR, an NIH-funded translational research operating suite where surgeons and interventionalists work with radiologists and technical experts to develop novel therapies to provide precise, minimally invasive, and effective treatments to patients. She leads the development of NousNav a low-cost open-source neuronavigation system for use in resource-limited settings.

Challenges and techniques for presurgical brain mapping with functional MRI.
Authors: Authors: Silva MA, See AP, Essayed WI, Golby AJ, Tie Y.
Neuroimage Clin
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Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone.
Authors: Authors: Arvold ND, Shi DD, Aizer AA, Norden AD, Reardon DA, Lee EQ, Nayak L, Dunn IF, Golby AJ, Johnson MD, Claus EB, Chiocca EA, Ligon KL, Wen PY, Alexander BM.
J Neurooncol
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SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research.
Authors: Authors: Norton I, Essayed W, Zhang F, Pujol S, Yarmarkovich A, Golby AJ, Kindlmann G, Wassermann D, Estepar RSJ, Rathi Y, Pieper S, Kikinis R, Johnson HJ, Westin CF, O'Donnell LJ.
Cancer Res
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Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol.
Authors: Authors: Hickman TT, Shuman ME, Johnson TA, Yang F, Rice RR, Rice IM, Chung EH, Wiemann R, Tinl M, Iracheta C, Chen G, Flynn P, Mondello MB, Thompson J, Meadows ME, Carroll RS, Yang HW, Xing H, Pilgrim D, Chiocca EA, Dunn IF, Golby AJ, Johnson MD.
J Neurosurg
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Retrospective study comparing model-based deformation correction to intraoperative magnetic resonance imaging for image-guided neurosurgery.
Authors: Authors: Luo M, Frisken SF, Weis JA, Clements LW, Unadkat P, Thompson RC, Golby AJ, Miga MI.
J Med Imaging (Bellingham)
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Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
Authors: Authors: Szaflarski JP, Gloss D, Binder JR, Gaillard WD, Golby AJ, Holland SK, Ojemann J, Spencer DC, Swanson SJ, French JA, Theodore WH.
Neurology
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Performance of unscented Kalman filter tractography in edema: Analysis of the two-tensor model.
Authors: Authors: Liao R, Ning L, Chen Z, Rigolo L, Gong S, Pasternak O, Golby AJ, Rathi Y, O'Donnell LJ.
Neuroimage Clin
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White matter tractography for neurosurgical planning: A topography-based review of the current state of the art.
Authors: Authors: Essayed WI, Zhang F, Unadkat P, Cosgrove GR, Golby AJ, O'Donnell LJ.
Neuroimage Clin
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Automated white matter fiber tract identification in patients with brain tumors.
Authors: Authors: O'Donnell LJ, Suter Y, Rigolo L, Kahali P, Zhang F, Norton I, Albi A, Olubiyi O, Meola A, Essayed WI, Unadkat P, Ciris PA, Wells WM, Rathi Y, Westin CF, Golby AJ.
Neuroimage Clin
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Applications of Ultrasound in the Resection of Brain Tumors.
Authors: Authors: Sastry R, Bi WL, Pieper S, Frisken S, Kapur T, Wells W, Golby AJ.
J Neuroimaging
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