Image of Alexandra Golby

Alexandra Golby, MD

Professor of Neurosurgery, Harvard Medical School
Professor of Radiology, Harvard Medical School
Department of Global Health and Social Medicine Affiliate
Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
Senior Surgeon, Brigham and Women's Hospital
Director of Image-guided Neurosurgery, Brigham and Women's Hospital
Co-Director AMIGO, Brigham and Women's Hospital

Dr. Golby is a Neurosurgeon and Haley Distinguished Chair in the Neurosciences at Brigham and Women’s Hospital in Boston. She is Professor of Neurosurgery and Professor of Radiology at Harvard Medical School.  She is also Principal Investigator of the Golby Lab, a surgical brain mapping laboratory. Dr. Golby’s clinical focus is on brain surgery for patients with brain tumors and epilepsy, especially those lesions which are intimately associated with critical brain structures. Her translational research is focused on advanced imaging and image guidance to improve care for patients undergoing intracranial neurosurgery. She has developed numerous technologies to help guide presurgical planning and intraoperative decision-making. She works closely with scientists across disciplines including computer science, applied mathematics, MR and ultrasound physics, radiology, neuroscience, and biomedical engineering. She is very involved with mentoring young clinicians and scientists both locally and globally. Dr. Golby was recently a Fulbright Global Scholar pursuing work to foster interdisciplinary collaborations between technical experts and clinicians in host countries Rwanda and Morocco to develop innovative medical technology suited to local conditions.

Dr. Golby received her BA from Yale University and MD from Stanford University School of Medicine. She completed residency training in Neurosurgery at Brigham and Women’s Hospital.

The Golby Lab is a multidisciplinary team of investigators using advanced imaging, image analysis, and computational strategies to develop novel approaches to guide neurosurgery. Areas of interest include using functional MRI to map cortical organization and diffusion MRI to map white matter connections, intra-operative imaging, navigation and guidance, and image guided therapies for brain tumors. She is the co-director of AMIGO, the advanced multi-modality Image guided OR, an NIH-funded translational research operating suite where surgeons and interventionalists work with radiologists and technical experts to develop novel therapies to provide precise, minimally invasive, and effective treatments to patients. She leads the development of NousNav a low-cost open-source neuronavigation system for use in resource-limited settings.

Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients.
Authors: Authors: Unadkat P, Fumagalli L, Rigolo L, Vangel MG, Young GS, Huang R, Mukundan S, Golby A, Tie Y.
J Neuroimaging
View full abstract on Pubmed
Preliminary Results Comparing Thin Plate Splines with Finite Element Methods for Modeling Brain Deformation during Neurosurgery using Intraoperative Ultrasound.
Authors: Authors: Frisken S, Luo M, Machado I, Unadkat P, Juvekar P, Bunevicius A, Toews M, Wells WM, Miga MI, Golby AJ.
Proc SPIE Int Soc Opt Eng
View full abstract on Pubmed
Neurosurgical Resection and Stereotactic Radiation Versus Stereotactic Radiation Alone in Patients with a Single or Solitary Brain Metastasis.
Authors: Authors: Lamba N, Cagney DN, Brigell RH, Martin AM, Besse LA, Catalano PJ, Phillips JG, Pashtan IM, Bi WL, Claus EB, Golby AJ, Dunn IF, Smith TR, Tanguturi SK, Haas-Kogan DA, Alexander BM, Aizer AA.
World Neurosurg
View full abstract on Pubmed
Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model.
Authors: Authors: McDannold N, Zhang Y, Supko JG, Power C, Sun T, Peng C, Vykhodtseva N, Golby AJ, Reardon DA.
Theranostics
View full abstract on Pubmed
Quantitative Wide-Field Imaging Techniques for Fluorescence Guided Neurosurgery.
Authors: Authors: Valdes PA, Juvekar P, Agar NYR, Gioux S, Golby AJ.
Front Surg
View full abstract on Pubmed
Using the variogram for vector outlier screening: application to feature-based image registration.
Authors: Authors: Luo J, Frisken S, Machado I, Zhang M, Pieper S, Golland P, Toews M, Unadkat P, Sedghi A, Zhou H, Mehrtash A, Preiswerk F, Cheng CC, Golby A, Sugiyama M, Wells WM.
Int J Comput Assist Radiol Surg
View full abstract on Pubmed
Non-rigid registration of 3D ultrasound for neurosurgery using automatic feature detection and matching.
Authors: Authors: Machado I, Toews M, Luo J, Unadkat P, Essayed W, George E, Teodoro P, Carvalho H, Martins J, Golland P, Pieper S, Frisken S, Golby A, Wells W.
Int J Comput Assist Radiol Surg
View full abstract on Pubmed
3D printing and intraoperative neuronavigation tailoring for skull base reconstruction after extended endoscopic endonasal surgery: proof of concept.
Authors: Authors: Essayed WI, Unadkat P, Hosny A, Frisken S, Rassi MS, Mukundan S, Weaver JC, Al-Mefty O, Golby AJ, Dunn IF.
J Neurosurg
View full abstract on Pubmed
Image Registration to Compensate for EPI Distortion in Patients with Brain Tumors: An Evaluation of Tract-Specific Effects.
Authors: Authors: Albi A, Meola A, Zhang F, Kahali P, Rigolo L, Tax CMW, Ciris PA, Essayed WI, Unadkat P, Norton I, Rathi Y, Olubiyi O, Golby AJ, O'Donnell LJ.
J Neuroimaging
View full abstract on Pubmed
Free water modeling of peritumoral edema using multi-fiber tractography: Application to tracking the arcuate fasciculus for neurosurgical planning.
Authors: Authors: Gong S, Zhang F, Norton I, Essayed WI, Unadkat P, Rigolo L, Pasternak O, Rathi Y, Hou L, Golby AJ, O'Donnell LJ.
PLoS One
View full abstract on Pubmed