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Navid Madani, PhD

Research Associate in Microbiology, Dana-Farber Cancer Institute
617-632-3994

Navid Madani, PhD, is a Senior Scientist in Dana-Farber Cancer Institute's Department of Cancer Immunology and Virology, with appointments at Harvard Medical School in the Departments of Microbiology and Global Health and Social Medicine. Currently, she is the principal investigator on a study that is optimizing the application of a CD4-mimetic small-molecule inhibitor of HIV-1 infection as topical microbicides. Madani has applied a deep knowledge of research and scientific-based approaches to public health projects in the areas of cancer and infectious diseases in the MENA region. The SHE Center was born out of her past decade of work in the region — bringing together crucial stakeholders within key populations.

Madani’s research emphasizes HIV/AIDS, drug discovery, and the development of a woman-controlled microbicide to halt HIV transmission. She uses a multidisciplinary approach to find preventive measures to inhibit HIV-1 transmission. Her studies have led to the biochemical characterization of two classes of small molecules that bind HIV-1 gp120 and inhibit HIV-1 entry.

Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.
Authors: Authors: Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB, Sodroski J, Finzi A.
J Virol
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Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.
Authors: Authors: Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JG.
Virol J
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Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.
Authors: Authors: Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB, Sodroski J.
J Virol
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Sindbis Virus-Pseudotyped Lentiviral Vectors Carrying VEGFR2-Specific Nanobody for Potential Transductional Targeting of Tumor Vasculature.
Authors: Authors: Ahani R, Roohvand F, Cohan RA, Etemadzadeh MH, Mohajel N, Behdani M, Shahosseini Z, Madani N, Azadmanesh K.
Mol Biotechnol
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Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
Authors: Authors: Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF.
EBioMedicine
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Improving the Quality and Quantity of HIV Data in the Middle East and North Africa: Key Challenges and Ways Forward.
Authors: Authors: Karamouzian M, Madani N, Doroudi F, Haghdoost AA.
Int J Health Policy Manag
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Response to letter to the editor re 'HIV Trends: Defining "The Middle East'.
Authors: Authors: Gökengin D, Madani N.
Int J Infect Dis
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Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.
Authors: Authors: Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB, Karlsson Hedestam GB, Haynes B, Sodroski J.
J Virol
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The state of harm reduction in the Middle East and North Africa: A focus on Iran and Morocco.
Authors: Authors: Himmich H, Madani N.
Int J Drug Policy
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Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.
Authors: Authors: Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB.
ACS Med Chem Lett
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