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Navid Madani, PhD

Research Associate in Microbiology, Dana-Farber Cancer Institute
617-632-3994

Navid Madani, PhD, is a Senior Scientist in Dana-Farber Cancer Institute's Department of Cancer Immunology and Virology, with appointments at Harvard Medical School in the Departments of Microbiology and Global Health and Social Medicine. Currently, she is the principal investigator on a study that is optimizing the application of a CD4-mimetic small-molecule inhibitor of HIV-1 infection as topical microbicides. Madani has applied a deep knowledge of research and scientific-based approaches to public health projects in the areas of cancer and infectious diseases in the MENA region. The SHE Center was born out of her past decade of work in the region — bringing together crucial stakeholders within key populations.

Madani’s research emphasizes HIV/AIDS, drug discovery, and the development of a woman-controlled microbicide to halt HIV transmission. She uses a multidisciplinary approach to find preventive measures to inhibit HIV-1 transmission. Her studies have led to the biochemical characterization of two classes of small molecules that bind HIV-1 gp120 and inhibit HIV-1 entry.

HIV/AIDS: trends in the Middle East and North Africa region.
Authors: Authors: Gökengin D, Doroudi F, Tohme J, Collins B, Madani N.
Int J Infect Dis
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Visa rules imperil collaboration.
Authors: Authors: Madani N.
Science
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CD4 mimetics sensitize HIV-1-infected cells to ADCC.
Authors: Authors: Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A.
Proc Natl Acad Sci U S A
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Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.
Authors: Authors: Tuyishime M, Danish M, Princiotto A, Mankowski MK, Lawrence R, Lombart HG, Esikov K, Berniac J, Liang K, Ji J, Ptak RG, Madani N, Cocklin S.
Bioorg Med Chem Lett
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Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer.
Authors: Authors: Pancera M, Druz A, Zhou T, O'Dell S, Louder M, Madani N, Herschhorn A, Sodroski J, Mascola JR, Kwong PD.
AIDS Res Hum Retroviruses
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CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies.
Authors: Authors: Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB, Wyatt R, Sodroski J.
J Virol
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Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.
Authors: Authors: Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith AB.
Acc Chem Res
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Women, culture and the HIV epidemic in MENA.
Authors: Authors: Chahil-Graf R, Madani N.
J Int AIDS Soc
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Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.
Authors: Authors: Lalonde JM, Le-Khac M, Jones DM, Courter JR, Park J, Schön A, Princiotto AM, Wu X, Mascola JR, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB.
ACS Med Chem Lett
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AIDS epidemic: Iran needs global support to fight HIV.
Authors: Authors: Modjarrad K, Mohraz M, Madani N.
Nature
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