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Navid Madani, Ph.D.

617-632-3994

Navid Madani, PhD, is a Senior Scientist in Dana-Farber Cancer Institute's Department of Cancer Immunology and Virology, with appointments at Harvard Medical School in the Departments of Microbiology and Global Health and Social Medicine. Currently, she is the principal investigator on a study that is optimizing the application of a CD4-mimetic small-molecule inhibitor of HIV-1 infection as topical microbicides. Madani has applied a deep knowledge of research and scientific-based approaches to public health projects in the areas of cancer and infectious diseases in the MENA region. The SHE Center was born out of her past decade of work in the region — bringing together crucial stakeholders within key populations.

Madani’s research emphasizes HIV/AIDS, drug discovery, and the development of a woman-controlled microbicide to halt HIV transmission. She uses a multidisciplinary approach to find preventive measures to inhibit HIV-1 transmission. Her studies have led to the biochemical characterization of two classes of small molecules that bind HIV-1 gp120 and inhibit HIV-1 entry.

HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism.
Authors: Authors: Tuzer F, Madani N, Kamanna K, Zentner I, LaLonde J, Holmes A, Upton E, Rajagopal S, McFadden K, Contarino M, Sodroski J, Chaiken I.
Proteins
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A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry.
Authors: Authors: Choi WT, Kumar S, Madani N, Han X, Tian S, Dong CZ, Liu D, Duggineni S, Yuan J, Sodroski JG, Huang Z, An J.
Biochemistry
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Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid.
Authors: Authors: Kortagere S, Madani N, Mankowski MK, Schön A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martín-García J, Freire E, Ptak RG, Sodroski J, Cocklin S, Smith AB.
J Virol
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Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.
Authors: Authors: LaLonde JM, Kwon YD, Jones DM, Sun AW, Courter JR, Soeta T, Kobayashi T, Princiotto AM, Wu X, Schön A, Freire E, Kwong PD, Mascola JR, Sodroski J, Madani N, Smith AB.
J Med Chem
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Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1a probed by a novel synthetically and modularly modified-chemokine analog.
Authors: Authors: Dong CZ, Tian S, Madani N, Choi WT, Kumar S, Liu D, Sodroski JG, Huang Z, An J.
Exp Biol Med (Maywood)
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Liposomes for HIV prophylaxis.
Authors: Authors: Malavia NK, Zurakowski D, Schroeder A, Princiotto AM, Laury AR, Barash HE, Sodroski J, Langer R, Madani N, Kohane DS.
Biomaterials
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Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.
Authors: Authors: Haim H, Strack B, Kassa A, Madani N, Wang L, Courter JR, Princiotto A, McGee K, Pacheco B, Seaman MS, Smith AB, Sodroski J.
PLoS Pathog
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Some binding-related drug properties are dependent on thermodynamic signature.
Authors: Authors: Schön A, Madani N, Smith AB, Lalonde JM, Freire E.
Chem Biol Drug Des
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Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.
Authors: Authors: Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith AB.
Bioorg Med Chem
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Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes.
Authors: Authors: Zhukovsky MA, Basmaciogullari S, Pacheco B, Wang L, Madani N, Haim H, Sodroski J.
PLoS One
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