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Edward Anthony Nardell, MD
Professor in the Department of Environmental Health; Professor of Global Health and Social Medicine

Dr. Nardell is a professor in the Departments of Medicine and of Global Health and Social Medicine at Harvard Medical School and an associate professor in the Departments of Immunology and Infectious Diseases and of Environmental Health at the Harvard School of Public Health. He is an associate in medicine in the Department of Medicine at Brigham and Women’s Hospital (BWH), in both the Division of Global Health Equity and the Pulmonary Division. His research interests involve the control of tuberculosis under resource-limited conditions, with a focus on the pathogenesis of drug-resistant tuberculosis, its airborne transmission, and transmission control in institutions. He is recently tested interventions to prevent transmission of multidrug-resistant tuberculosis (MDRTB) in a unique experimental facility in South Africa, in which large numbers of sentinel guinea pigs served to sample the air from a six-bed MDR-TB ward, part of an MDR-TB referral center. An early observation of this research led to new investigation on TB pathogenesis, specifically the possibility of transient TB infection in guinea pigs as well as humans. Another important finding is that effective treatment rapidly (within days) stops TB transmission, even due to MDR-TB. Further planned research will determine which drugs are responsible for this dramatic effect. Ongoing experiments are also studying the impact of inhaled TB drugs on TB transmission. Another long-standing research avenue is the application of germicidal irradiation to reduce airborne transmission. Dr. Nardell also is developing more efficient, less expensive UVGI fixtures for resource-limited settings. In addition, he has worked on developing and validating a computer-assisted design software package to facilitate planning of UV installations in buildings. He has also begun testing a novel, environmentally safe chemical vapor that may be effective in reducing airborne transmission.

Department of Environmental Health, Harvard School of Public Health Department of Immunology and Infectious Diseases, Harvard School of Public Health Department of Medicine, Brigham and Women's Hospital

FAST tuberculosis transmission control strategy speeds the start of tuberculosis treatment at a general hospital in Lima, Peru.
Authors: Authors: Tierney DB, Orvis E, Nathavitharana RR, Hurwitz S, Tintaya K, Vargas D, Segura P, de la Gala S, Lecca L, Mitnick CD, Nardell EA.
Infect Control Hosp Epidemiol
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Air Disinfection for Airborne Infection Control with a Focus on COVID-19: Why Germicidal UV is Essential†.
Authors: Authors: Nardell EA.
Photochem Photobiol
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Air Disinfection with Germicidal Ultraviolet: For this Pandemic and the Next.
Authors: Authors: Bergman R, Brenner D, Buonanno M, Eadie E, Forbes PD, Jensen P, Nardell EA, Sliney D, Vincent R, Welch D, Wood K.
Photochem Photobiol
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"If I've got latent TB, I would like to get rid of it": Derivation of the CARD (Constraints, Actions, Risks, and Desires) Framework informed by South African healthcare worker perspectives on latent tuberculosis treatment.
Authors: Authors: Nathavitharana RR, van der Westhuizen A, van der Westhuizen HM, Mishra H, Sampson A, Meintjes J, Nardell E, McDowell A, Theron G.
PLoS One
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Time to revise our tuberculosis infection-latency-disease model in high-burden settings.
Authors: Authors: Nardell EA.
Clin Infect Dis
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Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection.
Authors: Authors: Nardell EA, Nathavitharana RR.
JAMA
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Innovation and Knowledge Sharing Can Transform COVID-19 Infection Prevention Response.
Authors: Authors: Nathavitharana RR, Patel PK, Tierney DB, Mehrotra P, Lederer PA, Davis S, Nardell E.
J Hosp Med
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Cool but dangerous: How climate change is increasing the risk of airborne infections.
Authors: Authors: Nardell E, Lederer P, Mishra H, Nathavitharana R, Theron G.
Indoor Air
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Preventing Transmission of Mycobacterium Tuberculosis-A Refocused Approach.
Authors: Authors: Nardell EA.
Clin Chest Med
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Air disinfection in measles transmission hotspots.
Authors: Authors: Nardell E, Nathavitharana R.
Lancet
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