Edward Anthony Nardell
Edward Anthony Nardell, M.D.
Professor in the Department of Environmental Health; Professor of Global Health and Social Medicine

Dr. Nardell is a professor in the Departments of Medicine and of Global Health and Social Medicine at Harvard Medical School and an associate professor in the Departments of Immunology and Infectious Diseases and of Environmental Health at the Harvard School of Public Health. He is an associate in medicine in the Department of Medicine at Brigham and Women’s Hospital (BWH), in both the Division of Global Health Equity and the Pulmonary Division. His research interests involve the control of tuberculosis under resource-limited conditions, with a focus on the pathogenesis of drug-resistant tuberculosis, its airborne transmission, and transmission control in institutions. He is recently tested interventions to prevent transmission of multidrug-resistant tuberculosis (MDRTB) in a unique experimental facility in South Africa, in which large numbers of sentinel guinea pigs served to sample the air from a six-bed MDR-TB ward, part of an MDR-TB referral center. An early observation of this research led to new investigation on TB pathogenesis, specifically the possibility of transient TB infection in guinea pigs as well as humans. Another important finding is that effective treatment rapidly (within days) stops TB transmission, even due to MDR-TB. Further planned research will determine which drugs are responsible for this dramatic effect. Ongoing experiments are also studying the impact of inhaled TB drugs on TB transmission. Another long-standing research avenue is the application of germicidal irradiation to reduce airborne transmission. Dr. Nardell also is developing more efficient, less expensive UVGI fixtures for resource-limited settings. In addition, he has worked on developing and validating a computer-assisted design software package to facilitate planning of UV installations in buildings. He has also begun testing a novel, environmentally safe chemical vapor that may be effective in reducing airborne transmission.

Department of Environmental Health, Harvard School of Public Health Department of Immunology and Infectious Diseases, Harvard School of Public Health Department of Medicine, Brigham and Women's Hospital

Time to revise our tuberculosis infection-latency-disease model in high-burden settings.
Authors: Authors: Nardell EA.
Clin Infect Dis
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Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection.
Authors: Authors: Nardell EA, Nathavitharana RR.
JAMA
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Innovation and Knowledge Sharing Can Transform COVID-19 Infection Prevention Response.
Authors: Authors: Nathavitharana RR, Patel PK, Tierney DB, Mehrotra P, Lederer PA, Davis S, Nardell E.
J Hosp Med
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Cool but dangerous: How climate change is increasing the risk of airborne infections.
Authors: Authors: Nardell E, Lederer P, Mishra H, Nathavitharana R, Theron G.
Indoor Air
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Preventing Transmission of Mycobacterium Tuberculosis-A Refocused Approach.
Authors: Authors: Nardell EA.
Clin Chest Med
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Air disinfection in measles transmission hotspots.
Authors: Authors: Nardell E, Nathavitharana R.
Lancet
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The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis.
Authors: Authors: Dheda K, Gumbo T, Maartens G, Dooley KE, Murray M, Furin J, Nardell EA, Warren RM.
Lancet Respir Med
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Reducing tuberculosis transmission: a consensus document from the World Health Organization Regional Office for Europe.
Authors: Authors: Migliori GB, Nardell E, Yedilbayev A, D'Ambrosio L, Centis R, Tadolini M, van den Boom M, Ehsani S, Sotgiu G, Dara M.
Eur Respir J
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Treatment as prevention and other interventions to reduce transmission of multidrug-resistant tuberculosis.
Authors: Authors: Nathavitharana RR, Lederer P, Tierney DB, Nardell E.
Int J Tuberc Lung Dis
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Transmission of drug-resistant tuberculosis in HIV-endemic settings.
Authors: Authors: Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A.
Lancet Infect Dis
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