Edward Anthony Nardell
Edward Anthony Nardell, M.D.
Professor in the Department of Environmental Health; Professor of Global Health and Social Medicine

Dr. Nardell is a professor in the Departments of Medicine and of Global Health and Social Medicine at Harvard Medical School and an associate professor in the Departments of Immunology and Infectious Diseases and of Environmental Health at the Harvard School of Public Health. He is an associate in medicine in the Department of Medicine at Brigham and Women’s Hospital (BWH), in both the Division of Global Health Equity and the Pulmonary Division. His research interests involve the control of tuberculosis under resource-limited conditions, with a focus on the pathogenesis of drug-resistant tuberculosis, its airborne transmission, and transmission control in institutions. He is recently tested interventions to prevent transmission of multidrug-resistant tuberculosis (MDRTB) in a unique experimental facility in South Africa, in which large numbers of sentinel guinea pigs served to sample the air from a six-bed MDR-TB ward, part of an MDR-TB referral center. An early observation of this research led to new investigation on TB pathogenesis, specifically the possibility of transient TB infection in guinea pigs as well as humans. Another important finding is that effective treatment rapidly (within days) stops TB transmission, even due to MDR-TB. Further planned research will determine which drugs are responsible for this dramatic effect. Ongoing experiments are also studying the impact of inhaled TB drugs on TB transmission. Another long-standing research avenue is the application of germicidal irradiation to reduce airborne transmission. Dr. Nardell also is developing more efficient, less expensive UVGI fixtures for resource-limited settings. In addition, he has worked on developing and validating a computer-assisted design software package to facilitate planning of UV installations in buildings. He has also begun testing a novel, environmentally safe chemical vapor that may be effective in reducing airborne transmission.

Department of Environmental Health, Harvard School of Public Health Department of Immunology and Infectious Diseases, Harvard School of Public Health Department of Medicine, Brigham and Women's Hospital

Reducing tuberculosis transmission: a consensus document from the World Health Organization Regional Office for Europe.
Authors: Authors: Migliori GB, Nardell E, Yedilbayev A, D'Ambrosio L, Centis R, Tadolini M, van den Boom M, Ehsani S, Sotgiu G, Dara M.
Eur Respir J
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Treatment as prevention and other interventions to reduce transmission of multidrug-resistant tuberculosis.
Authors: Authors: Nathavitharana RR, Lederer P, Tierney DB, Nardell E.
Int J Tuberc Lung Dis
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Transmission of drug-resistant tuberculosis in HIV-endemic settings.
Authors: Authors: Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A.
Lancet Infect Dis
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Process measure of FAST tuberculosis infection control demonstrates delay in likely effective treatment.
Authors: Authors: Le H, Nguyen N, Tran P, Hoa N, Hung N, Moran A, Mossawi HJA, Kak N, Ahmedov S, Brooks MB, Nardell EA, Tierney DB.
Int J Tuberc Lung Dis
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Droplets, dust and guinea pigs: an historical review of tuberculosis transmission research, 1878-1940.
Authors: Authors: Donald PR, Diacon AH, Lange C, Demers AM, von Groote-Bidlingmaier F, Nardell E.
Int J Tuberc Lung Dis
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Designing and Evaluating Interventions to Halt the Transmission of Tuberculosis.
Authors: Authors: Dowdy DW, Grant AD, Dheda K, Nardell E, Fielding K, Moore DAJ.
J Infect Dis
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FAST implementation in Bangladesh: high frequency of unsuspected tuberculosis justifies challenges of scale-up.
Authors: Authors: Nathavitharana RR, Daru P, Barrera AE, Mostofa Kamal SM, Islam S, Ul-Alam M, Sultana R, Rahman M, Hossain MS, Lederer P, Hurwitz S, Chakraborty K, Kak N, Tierney DB, Nardell E.
Int J Tuberc Lung Dis
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The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.
Authors: Authors: Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM.
Lancet Respir Med
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Agents of change: The role of healthcare workers in the prevention of nosocomial and occupational tuberculosis.
Authors: Authors: Nathavitharana RR, Bond P, Dramowski A, Kotze K, Lederer P, Oxley I, Peters JA, Rossouw C, van der Westhuizen HM, Willems B, Ting TX, von Delft A, von Delft D, Duarte R, Nardell E, Zumla A.
Presse Med
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Inhaled drug treatment for tuberculosis: Past progress and future prospects.
Authors: Authors: Hickey AJ, Durham PG, Dharmadhikari A, Nardell EA.
J Control Release
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