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Grace Chan, MD, MPH, PhD

Associate Professor of Pediatrics and Epidemiology

Grace Chan is an epidemiologist and pediatrician, with expertise in maternal and child health. Her work focuses on the development of health and disease over the life course, using research to develop and implement sustainable clinical and public health interventions. As a perinatal and pediatric epidemiologist, Dr. Chan has led international collaborations with the World Health Organization and Save the Children. She serves on the technical advisory group with the Ministry of Health in Ethiopia.

Dr. Chan is a co-founder of HaSET, a global health and social justice NGO for mothers and children. She is an Associate Professor of Pediatrics at HMS and a practicing physician in the Division of Medical Critical Care at Boston Children’s Hospital. She is also an honorary faculty member at St Paul's Hospital Millennium Medical College in Addis Ababa, Ethiopia. Dr. Chan is a graduate of Harvard College and Harvard Medical School and trained in pediatrics at Boston Children’s Hospital and Boston Medical Center. She earned her PhD as an NIH Clinical Research Scholar from the Johns Hopkins Bloomberg School of Public Health, completing a post-doctoral fellowship at ICDDR,B in Bangladesh. Dr. Chan has trained health care workers, researchers and policy makers in India, Bangladesh, Indonesia, Tanzania, and Ethiopia; and mentored many talented students and fellows.

Affiliation:

Boston Children's Hopital

Dr. Chan’s research focuses on improving maternal and child health by using epidemiologic methods to discover and deliver evidence-based interventions. In collaboration with the World Health Organization (WHO) and Save the Children, she developed and tested models to scale up kangaroo mother care, an evidence-based intervention that reduces mortality among preterm and low birth weight babies up to 40%. These findings have influenced the recent global WHO guidelines on the care of preterm and low birth weight infants. Dr. Chan conducted a large-scale cohort study with 29,000 pregnant women and their newborns in seven low- and lower middle-income countries to determine the epidemiology and patterns of antimicrobial resistance of neonatal sepsis. Results demonstrated that over 90% of neonatal sepsis isolates were resistant to first-line antibiotics, which contributed to global and national programs on infection prevention and targeted antibiotic therapy.

Dr. Chan currently leads several large Gates-funded studies that focus on estimating the morbidity and mortality of women and young children in regions of the world like Ethiopia where reliable data and resources are limited. Through these studies, she is improving estimates of maternal and child health disease through surveillance in a rural field site of 80,000 and nested pregnancy and birth cohort, developing risk prediction models for adverse pregnancy and birth outcomes, and building research capacity of future generations.

Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study: protocol of a pragmatic clinical effectiveness study to improve birth outcomes in Ethiopia.
Authors: Authors: Lee AC, Abate FW, Mullany LC, Baye E, Berhane YY, Derebe MM, Eglovitch M, Fasil N, Olson IE, Kidane WT, Shiferaw T, Shiferie F, Tsegaye F, Tsegaye S, Yibeltal K, Chan GJ, Christian P, Isanaka S, Kang Y, Lu C, Mengistie MM, Molina RL, Stojanov MD, Van Dyk F, Tadesse AW, Wondale AT, Wylie BJ, Worku A, Berhane Y.
BMJ Paediatr Open
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Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS).
Authors: Authors: Thomson KM, Dyer C, Liu F, Sands K, Portal E, Carvalho MJ, Barrell M, Boostrom I, Dunachie S, Farzana R, Ferreira A, Frayne F, Hassan B, Jones E, Jones L, Mathias J, Milton R, Rees J, Chan GJ, Bekele D, Mahlet A, Basu S, Nandy RK, Saha B, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Syed NU, Mazarati JB, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, van Hasselt JGC, Walsh TR.
Lancet Infect Dis
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Birhan maternal and child health cohort: a study protocol.
Authors: Authors: Chan GJ, Hunegnaw BM, Van Wickle K, Mohammed Y, Hunegnaw M, Bekele C, Goddard FGB, Tadesse F, Bekele D.
BMJ Open
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Effect of birthweight measurement quality improvement on low birthweight prevalence in rural Ethiopia.
Authors: Authors: Baye E, Abate FW, Eglovitch M, Shiferie F, Olson IE, Shifraw T, Kidane WT, Yibeltal K, Tsegaye S, Derebe MM, Isanaka S, Wylie BJ, Molina RL, Chan GJ, Worku A, Mullany LC, Worku A, Berhane Y, Lee ACC.
Popul Health Metr
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Scaling up Kangaroo Mother Care in Ethiopia and India: a multi-site implementation research study.
Authors: Authors: Mony PK, Tadele H, Gobezayehu AG, Chan GJ, Kumar A, Mazumder S, Beyene SA, Jayanna K, Kassa DH, Mohammed HA, Estifanos AS, Kumar P, Jadaun AS, Hailu Abay T, Washington M, W/Gebriel F, Alamineh L, Fikre A, Kumar A, Trikha S, Ashebir Gebregizabher F, Kar A, Bilal SM, Belew ML, Debere MK, Krishna R, Dalpath SK, Amare SY, Mohan HL, Brune T, Sibley LM, Tariku A, Sahu A, Kumar T, Hadush MY, Gowda PD, Aziz K, Duguma D, Singh PK, Darmstadt GL, Agarwal R, Gebremariam DS, Martines J, Portela A, Jaiswal HV, Bahl R, Rao Pn S, Tadesse BT, Cranmer JN, Hailemariam D, Kumar V, Bhandari N, Medhanyie AA.
BMJ Glob Health
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Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries.
Authors: Authors: Sands K, Carvalho MJ, Portal E, Thomson K, Dyer C, Akpulu C, Andrews R, Ferreira A, Gillespie D, Hender T, Hood K, Mathias J, Milton R, Nieto M, Taiyari K, Chan GJ, Bekele D, Solomon S, Basu S, Chattopadhyay P, Mukherjee S, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Muhammad A, Mazarati JB, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, Walsh TR.
Nat Microbiol
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Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis.
Authors: Authors: Solomon S, Akeju O, Odumade OA, Ambachew R, Gebreyohannes Z, Van Wickle K, Abayneh M, Metaferia G, Carvalho MJ, Thomson K, Sands K, Walsh TR, Milton R, Goddard FGB, Bekele D, Chan GJ.
PLoS One
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Scoping review protocol on maternal, newborn and child health research in Ethiopia.
Authors: Authors: Chan GJ, Getnet M, Olowojesiku R, Min-Swe T, Hunegnaw B, Bekele D.
BMJ Open
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Kangaroo Mother Care implementation research to develop models for accelerating scale-up in India and Ethiopia: study protocol for an adequacy evaluation.
Authors: Authors: Medhanyie AA, Alemu H, Asefa A, Beyene SA, Gebregizabher FA, Aziz K, Bhandari N, Beyene H, Brune T, Chan G, Cranmer JN, Darmstadt G, Duguma D, Fikre A, Andualem BG, Gobezayehu AG, Mariam DH, Abay TH, Mohan HL, Jadaun A, Jayanna K, Kajal FNU, Kar A, Krishna R, Kumar A, Kumar V, Madhur TK, Belew ML, M R, Martines J, Mazumder S, Amin H, Mony PK, Muleta M, Pileggi-Castro C, Pn Rao S, Estifanos AS, Sibley LM, Singhal N, Tadele H, Tariku A, Lemango ET, Tadesse BT, Upadhyay R, Worku B, Hadush MY, Bahl R.
BMJ Open
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Distribution and determinants of pneumonia diagnosis using Integrated Management of Childhood Illness guidelines: a nationally representative study in Malawi.
Authors: Authors: Uwemedimo OT, Lewis TP, Essien EA, Chan GJ, Nsona H, Kruk ME, Leslie HH.
BMJ Glob Health
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