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Maha Reda Farhat, M.D., M.D.,C.M.

617-432-4598

Maha Farhat  holds an MD from the McGill University Faculty of Medicine and a MSc in biostatistics from the Harvard Chan School of Public Health. She is also a practicing physician at the Massachusetts General Hospital Division of Pulmonary and Critical Care Medicine.

Program in Global Surgery and Social Change

Dr. Farhat's research focuses on the development and application of methods for associating genotype and phenotype in infectious disease pathogens, with a strong emphasis on translation to better diagnostics and surveillance in resource-poor settings. To date, Farhat's work has focused on the pathogen Mycobacterium tuberculosis and spans the spectrum from computational analysis to field studies. She is PI and Co-Investigator on several large projects funded by NIH including the NIAID and the BD2K initiative.


DBMI Research Areas
DBMI Courses
Benchmarking within-sample minority variant detection with short-read sequencing in M. tuberculosis.
Authors: Authors: Mulaudzi S, Kulkarni S, Marin MG, Farhat MR.
bioRxiv
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An Integrated Data-Driven Model for Clinical Phenotyping of Tuberculosis Disease Severity.
Authors: Authors: Malatesta S, Jacobson KR, Horsburgh CR, Farhat M, Carney T, Gile KJ, Kolaczyk ED, White LF.
medRxiv
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The structural context of mutations in proteins predicts their effect on antibiotic resistance.
Authors: Authors: Green AG, Tasmin M, Vargas R, Farhat MR.
bioRxiv
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The Mycobacterium tuberculosis complex pangenome is small and shaped by sub-lineage-specific regions of difference.
Authors: Authors: Behruznia M, Marin M, Whiley DJ, Farhat MR, Thomas JC, Domingo-Sananes MR, Meehan CJ.
Elife
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Pitfalls of bacterial pan-genome analysis approaches: a case study of M. tuberculosis and two less clonal bacterial species.
Authors: Authors: Marin MG, Quinones-Olvera N, Wippel C, Behruznia M, Jeffrey BM, Harris M, Mann BC, Rosenthal A, Jacobson KR, Warren RM, Li H, Meehan CJ, Farhat MR.
Bioinformatics
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Genome-Wide Association Study Identifies a Locus at 17p13 to Be Associated With Intestinal Malrotation.
Authors: Authors: Gaitanidis A, Christensen MA, Dorken Gallastegi A, Breen KA, Velmahos GC, Kaafarani HMA, Farhat MR.
World J Surg
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Complete genome sequence of a virulent barcoded Mycobacterium tuberculosis str. Erdman commonly used for non-human primate infection studies.
Authors: Authors: Marin MG, Chase MR, Quinones N, Wakabayashi S, Mugahid D, Fortune SM, Farhat MR, Chao MC.
Microbiol Resour Announc
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Multivariable regression models improve accuracy and sensitive grading of antibiotic resistance mutations in Mycobacterium tuberculosis.
Authors: Authors: Kulkarni SG, Laurent S, Miotto P, Walker TM, Chindelevitch L, Nathanson CM, Ismail N, Rodwell TC, Farhat MR.
Nat Commun
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Patient Determinants and Effects on Adherence of Adverse Drug Reactions to Tuberculosis Treatment: A Prospective Cohort Analysis.
Authors: Authors: Tzelios CA, Malatesta S, Carney T, White LF, Weber SE, Thomson S, Theron D, Myers B, Parry CDH, Warren RM, Horsburgh CR, Farhat MR, Jacobson KR.
Clin Infect Dis
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Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures.
Authors: Authors: Luna MJ, Oluoch PO, Miao J, Culviner P, Papavinasasundaram K, Jaecklein E, Shell SS, Ioerger TR, Fortune SM, Farhat MR, Sassetti CM.
mBio
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