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Navid Madani, PhD
Research Associate in Microbiology, Dana-Farber Cancer Institute

Navid Madani, PhD, is a Senior Scientist in Dana-Farber Cancer Institute's Department of Cancer Immunology and Virology, with appointments at Harvard Medical School in the Departments of Microbiology and Global Health and Social Medicine. Madani’s research emphasizes HIV/AIDS, drug discovery, and the development of a woman-controlled microbicide to halt HIV transmission. She uses a multidisciplinary approach to find preventive measures to inhibit HIV-1 transmission. Her studies have led to the biochemical characterization of two classes of small molecules that bind HIV-1 gp120 and inhibit HIV-1 entry. Currently, she is the principal investigator on a study that is optimizing the application of a CD4-mimetic small-molecule inhibitor of HIV-1 infection as topical microbicides. Madani has applied a deep knowledge of research and scientific-based approaches to public health projects in the areas of cancer and infectious diseases in the MENA region. The SHE Center was born out of her past decade of work in the region — bringing together crucial stakeholders within key populations.

Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.
Authors: Authors: Fritschi CJ, Liang S, Mohammadi M, Anang S, Moraca F, Chen J, Madani N, Sodroski JG, Abrams CF, Hendrickson WA, Smith AB.
ACS Med Chem Lett
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Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges.
Authors: Authors: Aghila Rani KG, Hamad MA, Zaher DM, Sieburth SM, Madani N, Al-Tel TH.
Expert Opin Drug Discov
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COVID-19 response in the Middle East and north Africa: challenges and paths forward.
Authors: Authors: Karamouzian M, Madani N.
Lancet Glob Health
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The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Authors: Authors: Prévost J, Tolbert WD, Medjahed H, Sherburn RT, Madani N, Zoubchenok D, Gendron-Lepage G, Gaffney AE, Grenier MC, Kirk S, Vergara N, Han C, Mann BT, Chénine AL, Ahmed A, Chaiken I, Kirchhoff F, Hahn BH, Haim H, Abrams CF, Smith AB, Sodroski J, Pazgier M, Finzi A.
mBio
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Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins.
Authors: Authors: Zou S, Zhang S, Gaffney A, Ding H, Lu M, Grover JR, Farrell M, Nguyen HT, Zhao C, Anang S, Zhao M, Mohammadi M, Blanchard SC, Abrams C, Madani N, Mothes W, Kappes JC, Smith AB, Sodroski J.
J Virol
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Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein.
Authors: Authors: Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM.
PLoS Pathog
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Strain-dependent Activation and Inhibition of Human Immunodeficiency Virus (HIV-1) Entry by a Specific PF-68742 Stereoisomer.
Authors: Authors: Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB, Madani N, Sodroski J.
J Virol
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Fuzzy Modeling of the Enactment of Stigma by Healthcare Personnel Toward People Living with HIV in the Frame of Counterfactual Thinking: A Mixed-Method Approach.
Authors: Authors: Alipour Darvishi Z, Doroudi F, Madani N.
AIDS Res Hum Retroviruses
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A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection.
Authors: Authors: Princiotto AM, Vrbanac VD, Melillo B, Park J, Tager AM, Smith AB, Sodroski J, Madani N.
J Infect Dis
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A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.
Authors: Authors: Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski J.
Nat Commun
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