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Neil Gupta, M.D.

617-887-8300

Dr. Gupta is an internist, pediatrician, and public health specialist, and currently serves as Clinical Director for the NCD Synergies Project and the Lancet Commission for Reframing NCDs and Injuries for the Poorest Billion. He has previously worked as Chief Medical Officer for Partners In Health in Rwanda, where he was responsible for the strategy, design, and implementation of clinical programs provided in collaboration with the Ministry of Health. Dr. Gupta is Primary Investigator for the Simplifying Hepatitis C Antiviral Therapy for Elsewhere in the Developing World study, which aims to demonstrated safety and effectiveness of direct-acting antiviral treatment for Hepatitis C in Rwanda and develop treatment models for care. Previously, he served as Primary Investigator for the Population Health Implementation & Training grant, which implemented and then measured the impact of a comprehensive clinical and training program in rural Rwanda. Dr. Gupta is a graduate of University of Pennsylvania School of Medicine and Harvard School of Public Health, and he completed his residency training at Brigham & Women’s and Boston Children’s Hospitals. He is currently based in Addis Ababa, Ethiopia.

Dr. Gupta’s research focus is on the treatment outcomes of chronic hepatitis C infection in Rwanda. Through the Simplifying Hepatitis C Antiviral Therapy for Elsewhere in the Developing World(SHARED) study, Dr. Gupta’s team is evaluating the safety and efficacy of direct-acting antiviral (DAA) treatment in Rwanda. The study will also evaluate the epidemiology of hepatitis C infection in Rwanda, qualitatively explore the treatment experience of individual patients, and determine risk factors for treatment failure. The study will use outcomes of the study to develop simplified models for decentralized hepatitis C care delivery and promote greater access to DAAs in low-income countries. Dr. Gupta also studies the state of health service delivery for non-communicable diseases and injuries (NCDIs) in several countries throughout sub-Saharan Africa and South Asia supporting national NCD policy, planning, and advocacy. Through the Program in Global Noncommunicable Disease and Social Change, he has led the establishment and coordination of national NCDI Poverty Commissions to research the links between NCDIs and poverty and to plan for health sector interventions to address these challenges. Dr. Gupta has previously led operational research of outcomes of a large community-based HIV care and treatment program in rural Rwanda.

Risk factors for viral hepatitis C infection in Rwanda: results from a nationwide screening program.
Authors: Authors: Makuza JD, Liu CY, Ntihabose CK, Dushimiyimana D, Umuraza S, Nisingizwe MP, Umutesi J, Serumondo J, Mugeni SD, Semakula M, Gupta N, Hellard M, Nsanzimana S.
BMC Infect Dis
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Screening a nation for hepatitis C virus elimination: a cross-sectional study on prevalence of hepatitis C and associated risk factors in the Rwandan general population.
Authors: Authors: Umutesi J, Liu CY, Penkunas MJ, Makuza JD, Ntihabose CK, Umuraza S, Niyikora J, Serumondo J, Gupta N, Nsanzimana S.
BMJ Open
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Rwanda launches a 5-year national hepatitis C elimination plan: A landmark in sub-Saharan Africa.
Authors: Authors: Umutesi G, Shumbusho F, Kateera F, Serumondo J, Kabahizi J, Musabeyezu E, Ngwije A, Gupta N, Nsanzimana S.
J Hepatol
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Four delays of child mortality in Rwanda: a mixed methods analysis of verbal social autopsies.
Authors: Authors: Roder-DeWan S, Gupta N, Kagabo DM, Habumugisha L, Nahimana E, Mugeni C, Bucyana T, Hirschhorn LR.
BMJ Open
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Treatment of chronic hepatitis C virus infection in Rwanda with ledipasvir-sofosbuvir (SHARED): a single-arm trial.
Authors: Authors: Gupta N, Mbituyumuremyi A, Kabahizi J, Ntaganda F, Muvunyi CM, Shumbusho F, Musabeyezu E, Mukabatsinda C, Ntirenganya C, Van Nuil JI, Kateera F, Camus G, Damascene MJ, Nsanzimana S, Mukherjee J, Grant PM.
Lancet Gastroenterol Hepatol
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Causes of death and predictors of childhood mortality in Rwanda: a matched case-control study using verbal social autopsy.
Authors: Authors: Gupta N, Hirschhorn LR, Rwabukwisi FC, Drobac P, Sayinzoga F, Mugeni C, Nkikabahizi F, Bucyana T, Magge H, Kagabo DM, Nahimana E, Rouleau D, VanderZanden A, Murray M, Amoroso C.
BMC Public Health
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A retrospective study of neonatal case management and outcomes in rural Rwanda post implementation of a national neonatal care package for sick and small infants.
Authors: Authors: Nyishime M, Borg R, Ingabire W, Hedt-Gauthier B, Nahimana E, Gupta N, Hansen A, Labrecque M, Nkikabahizi F, Mutaganzwa C, Biziyaremye F, Mukayiranga C, Mwamini F, Magge H.
BMC Pediatr
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Pregnancy-associated breast cancer in rural Rwanda: the experience of the Butaro Cancer Center of Excellence.
Authors: Authors: Dusengimana JMV, Hategekimana V, Borg R, Hedt-Gauthier B, Gupta N, Troyan S, Shulman LN, Nzayisenga I, Fadelu T, Mpunga T, Pace LE.
BMC Cancer
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Is hepatitis C elimination possible in sub-Saharan Africa? The case of Rwanda.
Authors: Authors: Gupta N, Nsanzimana S.
Lancet Gastroenterol Hepatol
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The impact of "Option B" on HIV transmission from mother to child in Rwanda: An interrupted time series analysis.
Authors: Authors: Abimpaye M, Kirk CM, Iyer HS, Gupta N, Remera E, Mugwaneza P, Law MR.
PLoS One
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